BDBM296008 N-{[(2S)-1- ethylpyrrolidin-2- yl]methyl}-3-[(2R)-4- hydroxy-1-[3-methoxy-4- (1H-pyrazol-4- yl)benzoyl]pyrrolidin-2- yl]benzamide::US10112939, Example 49

SMILES CCN1CCC[C@H]1CNC(=O)c1cccc([C@H]2CC(O)CN2C(=O)c2ccc(-c3cn[nH]c3)c(OC)c2)c1

InChI Key InChIKey=LTDYXJYYKGBVFP-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 296008   

TargetRho-associated protein kinase 2(Human)
Bristol Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 296008BDBM296008(US10112939, Example 49 | N-{[(2S)-1- ethylpyrrolid...)
Affinity DataIC50: 43.4nMpH: 7.5Assay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2019
Entry Details
US Patent