BDBM296041 US10112939, Example 80

SMILES COc1cc(C(=O)N2CC(F)(F)C[C@@H]2c2cccc(C(=O)NC3CC3)c2)ccc1-c1cn[nH]c1

InChI Key InChIKey=RUTYJROQPPDTCY-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 296041   

TargetRho-associated protein kinase 2(Human)
Bristol Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 296041BDBM296041(US10112939, Example 80)
Affinity DataIC50: 5.40nMpH: 7.5Assay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2019
Entry Details
US Patent