BDBM296062 4-(4-{2-[3-(2,2-Difluoroethoxy)phenyl]pyrrolidine-1-carbonyl}-2-methoxyphenyl)-1H-pyrazole::US10112939, Example 102

SMILES COc1cc(ccc1-c1cn[nH]c1)C(=O)N1CCCC1c1cccc(OCC(F)F)c1

InChI Key InChIKey=SDBWBGQWWGQOPJ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 296062   

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 296062BDBM296062(US10112939, Example 102 | 4-(4-{2-[3-(2,2-Difluoro...)
Affinity DataIC50: 411nMpH: 7.5Assay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2019
Entry Details
US Patent