BDBM296072 US10112939, Example 112

SMILES CCNS(=O)(=O)c1cccc([C@H]2CCCN2C(=O)c2ccc(-c3cn[nH]c3)c(OC)c2)c1

InChI Key InChIKey=PQIAMEKWAXTLAP-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 296072   

TargetRho-associated protein kinase 2(Human)
Bristol Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 296072BDBM296072(US10112939, Example 112)
Affinity DataIC50: 15.2nMpH: 7.5Assay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2019
Entry Details
US Patent