BDBM29719 Pyridoimidazolone, 5s

SMILES Cn1c(=O)[nH]c2c(Oc3ccc(NC(=O)Nc4cc(C(F)(F)F)ccc4F)cc3)ccnc21

InChI Key InChIKey=LRLXPNPIOREGIL-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 29719   

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
The Institute of Cancer Research

LigandChemical structure of BindingDB Monomer ID 29719BDBM29719(Pyridoimidazolone, 5s)
Affinity DataIC50: 46nMpH: 7.2 T: 2°CAssay Description:The biological activities (IC50s) of the compounds were determined against the B-RAF (V600E) mutant enzyme in vitro. GST-MEK1, B-RAF (V600E), and inh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed