BDBM297402 US10117858, Example 5::US20240058315, Example 5

SMILES COc1nc(C(=O)NC[C@](C)(O)C(F)(F)F)c(N)cc1C(F)(F)F

InChI Key InChIKey=USHQRIKZLHNPQR-UHFFFAOYSA-N

Data  8 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 297402   

TargetCystic fibrosis transmembrane conductance regulator(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM297402(US10117858, Example 5 | US20240058315, Example 5)
Affinity DataEC50:  39nMAssay Description:Potentiation of CFTR F508 deletion mutant (unknown origin) expressed in HBE cells assessed as change in short circuit current in presence of forskoli...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM297402(US10117858, Example 5 | US20240058315, Example 5)
Affinity DataEC50:  47nMAssay Description:Potentiation of CFTR F508del mutant (unknown origin) expressed in CHO cells assessed as chloride transport by measuring membrane potential incubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM297402(US10117858, Example 5 | US20240058315, Example 5)
Affinity DataEC50:  50nMAssay Description:Fischer Rat Thyroid (FRT) epithelial cells, stably expressing human ΔF508-CFTR were used as monolayer cultures on permeable supports. Cl− ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2019
Entry Details
US Patent

LigandPNGBDBM297402(US10117858, Example 5 | US20240058315, Example 5)
Affinity DataEC50:  50nMAssay Description:Fischer Rat Thyroid (FRT) epithelial cells, stably expressing human ΔF508-CFTR were used as monolayer cultures on permeable supports. Cl− ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent

TargetCystic fibrosis transmembrane conductance regulator(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM297402(US10117858, Example 5 | US20240058315, Example 5)
Affinity DataEC50:  72nMAssay Description:Potentiation of wild type CFTR (unknown origin) expressed in HBE cells assessed as change in short circuit current in presence of forskolin and amilo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM297402(US10117858, Example 5 | US20240058315, Example 5)
Affinity DataEC50:  79nMAssay Description:Potentiation of CFTR F508del mutant (unknown origin) expressed in FRT cells assessed as chloride transport by measuring membrane potential in presenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM297402(US10117858, Example 5 | US20240058315, Example 5)
Affinity DataEC50:  113nMAssay Description:Potentiation of wild-type CFTR (unknown origin) expressed in FRT cells assessed as chloride transport by measuring membrane potential in presence of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetCystic fibrosis transmembrane conductance regulator(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM297402(US10117858, Example 5 | US20240058315, Example 5)
Affinity DataEC50:  497nMAssay Description:Potentiation of CFTR G551D mutant (unknown origin) expressed in FRT cells assessed as chloride transport by measuring membrane potential in presence ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed