BDBM29877 alkynyl ether, 19

SMILES OC(=O)COc1ccc(Sc2ccc(COc3ccc(cc3)C(F)(F)F)cc2OCC#C)c2CCCCc12

InChI Key InChIKey=ZCORSQTXEMWYOI-UHFFFAOYSA-N

Data  3 KI  3 EC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 29877   

TargetPeroxisome proliferator-activated receptor delta(Human)
Amgen

LigandBDBM29877(alkynyl ether, 19)Copy SMILESCopy InChI

Affinity DataKi:  7nM EC50:  52nMAssay Description:The human PPARdelta ligand binding was directly measured using a scintillation proximity assay. Plates were read on a Packard TopCount. IC50 values f...More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
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Ligand InfoPC cidPC sidSimilars

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TargetPeroxisome proliferator-activated receptor alpha(Human)
Amgen

LigandBDBM29877(alkynyl ether, 19)Copy SMILESCopy InChI

Affinity DataKi:  960nM ΔG°:  -8.12kcal/mole EC50:  3.90E+3nMpH: 7.1 T: 22°CAssay Description:The human PPARalpha ligand binding was directly measured using a scintillation proximity assay. Plates were read on a Packard TopCount. IC50 values f...More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails ArticlePubMed
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TargetPeroxisome proliferator-activated receptor gamma(Human)
Amgen

LigandBDBM29877(alkynyl ether, 19)Copy SMILESCopy InChI

Affinity DataKi:  1.20E+3nM EC50:  4.90E+3nMAssay Description:The human PPARgamma ligand binding was directly measured using a filtration assay in a UniFilter 350 96-well assay plate (Polyfiltronics). The reacti...More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails ArticlePubMed
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