BDBM298815 US10125118, Example 221::US10947215, Example 221

SMILES Cn1cc(cn1)-c1cnc(N)c(c1)C(=O)N[C@H]1CCC[C@@H]1OCc1ccc(cc1)-c1ccc(cc1)C(C)(C)N1CCN(CCO)CC1

InChI Key InChIKey=BMHLOOSWUGXQCM-UHFFFAOYSA-N

Data  10 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 298815   

TargetTyrosine-protein kinase Mer(Human)
AbbVie Inc.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 298815BDBM298815(US10125118, Example 221 | US10947215, Example 221)
Affinity DataIC50: 0.290nMAssay Description:Inhibition of N-terminal GST-fused recombinant human MER (528 to 999 residues) extracted from baculovirus expression system preincubated for 30 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetTyrosine-protein kinase Mer(Human)
AbbVie Inc.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 298815BDBM298815(US10125118, Example 221 | US10947215, Example 221)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of N-terminal GST-fused recombinant human MerTk cytoplasmic domain (528 to end residues) expressed in baculovirus expression system using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetTyrosine-protein kinase receptor UFO(Human)
Abbvie, Inc

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 298815BDBM298815(US10125118, Example 221 | US10947215, Example 221)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of N-terminal His-tagged recombinant human Axl (473 to end residues) expressed in baculovirus-infected Sf9 cells using biotin-labeled TK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetTyrosine-protein kinase receptor UFO(Human)
Abbvie, Inc

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 298815BDBM298815(US10125118, Example 221 | US10947215, Example 221)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of N-terminal his-tagged recombinant human Axl (473 to end residues) extracted from baculovirus infected Sf9 cells preincubated for 30 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetTyrosine-protein kinase Mer/receptor UFO(Human)
Dong-A Socio Holdings

US Patent
LigandChemical structure of BindingDB Monomer ID 298815BDBM298815(US10125118, Example 221 | US10947215, Example 221)
Affinity DataIC50: 10nMAssay Description:For the SAR (structure-activity relationship) and compound screening, LanthaScreen TR-FRET (Time-Resolved fluorescence energy transfer) assay was emp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
US Patent

TargetTyrosine-protein kinase Mer(Human)
AbbVie Inc.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 298815BDBM298815(US10125118, Example 221 | US10947215, Example 221)
Affinity DataIC50: 10nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2019
Entry Details
US Patent

TargetTyrosine-protein kinase Mer(Human)
AbbVie Inc.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 298815BDBM298815(US10125118, Example 221 | US10947215, Example 221)
Affinity DataEC50:  19nMAssay Description:Inhibition of phosphorylation of Myc-tagged human MerTK expressed in mouse BaF3 cells by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetTyrosine-protein kinase Mer(Human)
AbbVie Inc.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 298815BDBM298815(US10125118, Example 221 | US10947215, Example 221)
Affinity DataEC50:  19nMAssay Description:Inhibition of Myc-tagged/TEL dimerization domain-fused human MerTk kinase domain expressed in mouse BaF3 cells assessed as inhibition of MerTk phosph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetTyrosine-protein kinase receptor TYRO3(Human)
AbbVie Inc.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 298815BDBM298815(US10125118, Example 221 | US10947215, Example 221)
Affinity DataIC50: 167nMAssay Description:Inhibition of N-terminal GST-tagged recombinant human Tyro-3 (455 to end residues) extracted from baculovirus infected Sf9 cells preincubated for 30 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetActivated CDC42 kinase 1(Human)
Abbvie, Inc

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 298815BDBM298815(US10125118, Example 221 | US10947215, Example 221)
Affinity DataIC50: 188nMAssay Description:Inhibition of TNK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 298815BDBM298815(US10125118, Example 221 | US10947215, Example 221)
Affinity DataIC50: 435nMAssay Description:Inhibition of MAP4K1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 5(Homo sapiens)
Abbvie, Inc

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 298815BDBM298815(US10125118, Example 221 | US10947215, Example 221)
Affinity DataIC50: 530nMAssay Description:Inhibition of MAP4K5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed