BDBM299124 (6S,8R)-6-(4-(2- (3-(fluoromethyl) azetidin-1- yl)ethoxy)-2- methoxyphenyl)- 7-((3- fluorooxetan-3- yl)methyl)-8- methyl-6,7,8,9- tetrahydro-3H- pyrazolo[4,3- f]isoquinoline::US10125135, Example 13
SMILES COc1cc(OCCN2CC(CF)C2)ccc1[C@H]1N(CC2(F)COC2)[C@H](C)Cc2c1ccc1[nH]ncc21
InChI Key
Data 3 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 299124
Affinity DataIC50: 3.70nMAssay Description:The ability of compounds to bind to isolated Estrogen Receptor Alpha Ligand binding domain (ER alpha LBD (GST)) was assessed in competition assays us...More data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Displacement of fluormone ES2 green reagent from human GST-tagged ERalpha LBD (282 to 595 residues) expressed in baculovirus infected insect cells in...More data for this Ligand-Target Pair
Affinity DataIC50: 0.251nMAssay Description:Induction of ERalpha degradation in human MCF7 cells assessed as decrease in ER-alpha level incubated for 18 to 24 hrs by Alexa fluor 488/Hoechst sta...More data for this Ligand-Target Pair