BDBM299189 N-(1H-Indazol-5-yl)-2-(isoindolin-2-yl)-5,7-dihydrofuro[3,4-d]pyrimidin-4-amine::US10125144, Example 17

SMILES c1ccc2c(c1)CN(c1nc3c(c(Nc4ccc5[nH]ncc5c4)n1)COC3)C2

InChI Key InChIKey=KAIFCONTMLZMTE-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 299189   

TargetRho-associated protein kinase 1(Human)
Kadmon

US Patent
LigandChemical structure of BindingDB Monomer ID 299189BDBM299189(US10125144, Example 17 | N-(1H-Indazol-5-yl)-2-(is...)
Affinity DataIC50: 1.00E+4nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2019
Entry Details
US Patent