BDBM301013 4-[5-morpholin-4-yl-1-[[(3R)- pyrrolidin-3-yl]methyl]pyrrolo[3,2- b]pyridin-6-yl]benzonitrile::US10131664, Example 6::US10543198, Example 6::US10864202, Example 6

SMILES N#Cc1ccc(cc1)-c1cc2n(C[C@@H]3CCNC3)ccc2nc1N1CCOCC1

InChI Key InChIKey=KCOZUZQZUXJBON-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 301013   

TargetLysine-specific histone demethylase 1A(Human)
Celgene Quanticel Research

US Patent
LigandChemical structure of BindingDB Monomer ID 301013BDBM301013(4-[5-morpholin-4-yl-1-[[(3R)- pyrrolidin-3-yl]meth...)
Affinity DataIC50: 550nMAssay Description:The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2021
Entry Details
US Patent

TargetLysine-specific histone demethylase 1A(Human)
Celgene Quanticel Research

US Patent
LigandChemical structure of BindingDB Monomer ID 301013BDBM301013(4-[5-morpholin-4-yl-1-[[(3R)- pyrrolidin-3-yl]meth...)
Affinity DataIC50: 550nMAssay Description:The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetLysine-specific histone demethylase 1A(Human)
Celgene Quanticel Research

US Patent
LigandChemical structure of BindingDB Monomer ID 301013BDBM301013(4-[5-morpholin-4-yl-1-[[(3R)- pyrrolidin-3-yl]meth...)
Affinity DataIC50: 550nMAssay Description:This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2020
Entry Details
US Patent