BDBM301069 4-[2-(2,8-diazaspiro[4.5]decan-8-yl)-5- [1-(2,2,2-trifluoroethyl)pyrazol-4- yl]pyrimidin-4-yl]benzonitrile::BDBM301128::US10131664, Example 62

SMILES FC(F)(F)Cn1cc(cn1)-c1cnc(nc1-c1ccc(cc1)C#N)N1CCC2(CCNC2)CC1

InChI Key InChIKey=UUNDFHFDDVTMFX-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 301069   

TargetLysine-specific histone demethylase 1A(Human)
Celgene Quanticel Research

US Patent
LigandChemical structure of BindingDB Monomer ID 301069BDBM301069(4-[2-(2,8-diazaspiro[4.5]decan-8-yl)-5- [1-(2,2,2-...)
Affinity DataIC50: 10nMAssay Description:The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetLysine-specific histone demethylase 1A(Human)
Celgene Quanticel Research

US Patent
LigandChemical structure of BindingDB Monomer ID 301069BDBM301069(4-[2-(2,8-diazaspiro[4.5]decan-8-yl)-5- [1-(2,2,2-...)
Affinity DataIC50: 10nMAssay Description:The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent