BDBM302664 N5-(2,2-Difluorobenzo [d][1,3]dioxol-5-yl)-2- (3,4-difluorophenyl)- 6,7-dihydropyrazolo [1,5-a]pyrazine- 3,5(4H)- dicarboxamide::US9598423, Example 232

SMILES NC(=O)c4c(c1ccc(F)c(F)c1)nn5CCN(C(=O)Nc3ccc2OC(F)(F)Oc2c3)Cc45

InChI Key InChIKey=YJSZRMVRONBTRL-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 302664   

TargetCasein kinase I isoform epsilon(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 302664BDBM302664(N5-(2,2-Difluorobenzo [d][1,3]dioxol-5-yl)-2- (3,4...)
Affinity DataIC50: 10nMAssay Description:The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetCasein kinase I isoform delta(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 302664BDBM302664(N5-(2,2-Difluorobenzo [d][1,3]dioxol-5-yl)-2- (3,4...)
Affinity DataIC50: 10nMAssay Description:The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent