BDBM303801 2-(11′-Chloro-2′,5′-dioxo-2′,5′,6′,8′-tetrahydro-3′H-spiro[cyclopropane-1,7′-pyrido[3,4-e][3]benzazocine]-3′-yl)-4-methoxy-N-(2-methyl-3-oxo-2,3-dihydro-1H-indazol-6-yl)butanamide (Stereoisomer Mixture)::US10138236, Example 19

SMILES COCCC(C(=O)Nc1ccc2c(c1)[nH]n(C)c2=O)n1cc2c(cc1=O)-c1cc(Cl)ccc1CC1(CC1)NC2=O

InChI Key InChIKey=DAQPCJFUMAFGPS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 303801   

TargetPlasma kallikrein(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM303801(2-(11′-Chloro-2′,5′-dioxo-2̸...)
Affinity DataIC50:  230nMAssay Description:o determine the plasma kallikrein inhibition of the substances according to the invention, a biochemical test system is used which utilizes the react...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetCoagulation factor XI(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM303801(2-(11′-Chloro-2′,5′-dioxo-2̸...)
Affinity DataIC50:  8.40nMAssay Description:The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent