BDBM303897 N-Cyclopropyl-4-methyl-3-(1 -methyl-I H-[1,4′]bipyrazolyl-4-yl)-benzamide::US10138241, Example 84::US11130754, Example 84::US12139484, Example 84

SMILES Cc1ccc(cc1-c1cnn(c1)-c1cnn(C)c1)C(=O)NC1CC1

InChI Key InChIKey=HWEIRUCYAFJXQK-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 303897   

TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 303897BDBM303897(N-Cyclopropyl-4-methyl-3-(1 -methyl-I H-[1,4′...)
Affinity DataIC50: 23nMAssay Description:Method: In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/18/2025
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 303897BDBM303897(N-Cyclopropyl-4-methyl-3-(1 -methyl-I H-[1,4′...)
Affinity DataIC50: 23nMAssay Description:In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). After 15...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 303897BDBM303897(N-Cyclopropyl-4-methyl-3-(1 -methyl-I H-[1,4′...)
Affinity DataIC50: 23nMAssay Description:Method: In a 384-well plate, test compound diluted in assay buffer (1% DMSO final) is mixed with 8His-RIPK2 FL enzyme (final concentration of 8 nM). ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2022
Entry Details
US Patent