BDBM304147 (R)-2-(1-((4-carboxyphenyl)amino)-3-(3,3-difluorocyclobutyl)-1-oxopropan-2-yl)-5-(3-chloro-6-(difluoromethoxy)-2-fluorophenyl)pyridine 1-oxide::US10143681, Example 50

SMILES OC(=O)c1ccc(NC(=O)[C@H](CC2CC(F)(F)C2)c2ccc(c[n+]2[O-])-c2c(F)c(Cl)ccc2OC(F)F)cc1

InChI Key InChIKey=BHJAKKAIHULLLP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 304147   

TargetCoagulation factor XI(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 304147BDBM304147((R)-2-(1-((4-carboxyphenyl)amino)-3-(3,3-difluoroc...)
Affinity DataIC50: 3.80nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIa can be determined using a relevant purified serine...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2019
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 304147BDBM304147((R)-2-(1-((4-carboxyphenyl)amino)-3-(3,3-difluoroc...)
Affinity DataIC50: 47nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Kallikrein can be determined using a relevant purified serine protease, a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2019
Entry Details
US Patent