BDBM304288 US10144715, Compound 1-1::US10144715, Compound 2-2::tert-butyl (R)-2-isopropyl-4-(3-(methylsulfonyl)phenyl)piperazine-1-carboxylate

SMILES CC(C)[C@@H]1CN(CCN1C(=O)OC(C)(C)C)c1cccc(c1)S(C)(=O)=O

InChI Key InChIKey=HDOWNKAPIXMAAE-UHFFFAOYSA-N

Data  4 KI  1 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 304288   

TargetOxysterols receptor LXR-beta(Human)
Vitae Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 304288BDBM304288(US10144715, Compound 2-2 | tert-butyl (R)-2-isopro...)
Affinity DataEC50:  15nMAssay Description:This assay is based on the ability of the LXR-LBDs (LXRα and LXRβ) to recruit and interact with a co-activator peptide. This assay was run ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2019
Entry Details
US Patent

TargetOxysterols receptor LXR-beta(Human)
Vitae Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 304288BDBM304288(US10144715, Compound 2-2 | tert-butyl (R)-2-isopro...)
Affinity DataKi:  157nMAssay Description:Compounds of the invention were assessed in a competition binding assay where different concentrations of compounds were incubated with the LXR ligan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2019
Entry Details
US Patent

TargetOxysterols receptor LXR-alpha(Human)
Vitae Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 304288BDBM304288(US10144715, Compound 2-2 | tert-butyl (R)-2-isopro...)
Affinity DataEC50:  409nMAssay Description:This assay is based on the ability of the LXR-LBDs (LXRα and LXRβ) to recruit and interact with a co-activator peptide. This assay was run ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2019
Entry Details
US Patent

TargetOxysterols receptor LXR-alpha(Human)
Vitae Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 304288BDBM304288(US10144715, Compound 2-2 | tert-butyl (R)-2-isopro...)
Affinity DataKi:  1.69E+3nMAssay Description:Compounds of the invention were assessed in a competition binding assay where different concentrations of compounds were incubated with the LXR ligan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2019
Entry Details
US Patent

TargetOxysterols receptor LXR-beta(Human)
Vitae Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 304288BDBM304288(US10144715, Compound 2-2 | tert-butyl (R)-2-isopro...)
Affinity DataKi:  1.93E+3nMAssay Description:Compounds of the invention were assessed in a competition binding assay where different concentrations of compounds were incubated with the LXR ligan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2019
Entry Details
US Patent

TargetOxysterols receptor LXR-alpha(Human)
Vitae Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 304288BDBM304288(US10144715, Compound 2-2 | tert-butyl (R)-2-isopro...)
Affinity DataKi: >3.33E+3nMAssay Description:Compounds of the invention were assessed in a competition binding assay where different concentrations of compounds were incubated with the LXR ligan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2019
Entry Details
US Patent

TargetOxysterols receptor LXR-alpha(Human)
Vitae Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 304288BDBM304288(US10144715, Compound 2-2 | tert-butyl (R)-2-isopro...)
Affinity DataEC50:  2.32E+4nMAssay Description:This assay is based on the ability of the LXR-LBDs (LXRα and LXRβ) to recruit and interact with a co-activator peptide. This assay was run ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2019
Entry Details
US Patent

TargetOxysterols receptor LXR-beta(Human)
Vitae Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 304288BDBM304288(US10144715, Compound 2-2 | tert-butyl (R)-2-isopro...)
Affinity DataIC50: 5.00E+4nMAssay Description:This assay is based on the ability of the LXR-LBDs (LXRα and LXRβ) to recruit and interact with a co-activator peptide. This assay was run ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2019
Entry Details
US Patent