BDBM30641 US8853193, 32-26

SMILES CC(CF)Oc1cc(F)ccc1Nc1ncnc2sc(C(=O)NCCCN(C)C)c(C)c12

InChI Key InChIKey=WTCFYBGLEUOJNE-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 30641   

TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM30641(US8853193, 32-26)
Affinity DataIC50: 7nMpH: 7.4 T: 2°CAssay Description:Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2015
Entry Details
US Patent

TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM30641(US8853193, 32-26)
Affinity DataIC50: 16nMAssay Description:Inhibition of MNK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM30641(US8853193, 32-26)
Affinity DataIC50: 16nMAssay Description:Inhibition of MNK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
Ocean University of China and Laboratory For Marine Drugs and Bioproducts

Curated by ChEMBL
LigandPNGBDBM30641(US8853193, 32-26)
Affinity DataIC50: 23nMAssay Description:Inhibition of MNK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
Ocean University of China and Laboratory For Marine Drugs and Bioproducts

Curated by ChEMBL
LigandPNGBDBM30641(US8853193, 32-26)
Affinity DataIC50: 23nMAssay Description:Inhibition of MNK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed