BDBM307930 trans-N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-N′-(pyridin-3-ylmethyl)cyclohexane-1,4-diamine::US9650358, Example 226

SMILES Fc1cccc(Cn2cnc3ccc(-c4cc(N[C@H]5CC[C@H](NCc6cccnc6)CC5)ncc4Cl)cc32)c1

InChI Key InChIKey=SXPLEPVGURNMBT-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 307930   

TargetCyclin-dependent kinase 9(Human)
Abbvie

US Patent
LigandChemical structure of BindingDB Monomer ID 307930BDBM307930(US9650358, Example 226 | trans-N-{5-chloro-4-[1-(...)
Affinity DataIC50: 37nMAssay Description:CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were directly added in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2019
Entry Details
US Patent