BDBM310668 4-(4-Fluoropiperidine-1-carbonyl)-5-(8-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)quinolin-5-yl)-N-(2-hydroxy-2-methylpropyl)thiazole-2-carboxamide::US10150762, Example 13

SMILES CC(C)(O)CNC(=O)c1nc(C(=O)N2CCC(F)CC2)c(s1)-c1ccc(c2ncccc12)C(O)(C(F)(F)F)C(F)(F)F

InChI Key InChIKey=JNACMGUBYJYYFF-UHFFFAOYSA-N

Data  1 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 310668   

TargetNuclear receptor ROR-gamma(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 310668BDBM310668(US10150762, Example 13 | 4-(4-Fluoropiperidine-1-c...)
Affinity DataKd:  420nMAssay Description:Project compounds were arranged in a pre-dosed mother plate (Greiner Bio-one) wherein compounds are serially diluted in 100% DMSO by 1:2 from a high ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 310668BDBM310668(US10150762, Example 13 | 4-(4-Fluoropiperidine-1-c...)
Affinity DataIC50: 1.10E+3nMAssay Description:Cells used in this assay were transiently co-transfected with three different plasmids, one expressing the GAL4-DNA binding domain (DBD)-RORγt f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
US Patent