BDBM311147 (S)-2-(4-((7-chloro-1-methyl-1H- indazol-4-yl)oxy)phenyl)-6-(1,2- dihydroxyethyl)pyrimidine-4- carboxamide::US10155752, Compound 34::US9834543, Compound 34

SMILES Cn1ncc2c(Oc3ccc(cc3)-c3nc(cc(n3)C(N)=O)[C@H](O)CO)ccc(Cl)c12

InChI Key InChIKey=HRZLCFGXAYYNML-UHFFFAOYSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 311147   

TargetSodium channel protein type 9 subunit alpha(Human)
Purdue Pharma

US Patent
LigandPNGBDBM311147(US10155752, Compound 34 | (S)-2-(4-((7-chloro-1-me...)
Affinity DataKi:  120nMAssay Description:The hNav1.7 expressing HEK-293 cells are plated on 35 mm culture dishes pre-coated with poly-D-lysine in standard DMEM culture media (Mediatech, Inc....More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2019
Entry Details
US Patent

TargetSodium channel protein type 9 subunit alpha(Human)
Purdue Pharma

US Patent
LigandPNGBDBM311147(US10155752, Compound 34 | (S)-2-(4-((7-chloro-1-me...)
Affinity DataKi:  120nMAssay Description:In vitro assays were performed in a recombinant cell line expressing cDNA encoding the alpha subunit (Nav1.7, SCN9a, PN1, NE) of human Nav1.7 (Access...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2019
Entry Details
US Patent

TargetSodium channel protein type 9 subunit alpha(Human)
Purdue Pharma

US Patent
LigandPNGBDBM311147(US10155752, Compound 34 | (S)-2-(4-((7-chloro-1-me...)
Affinity DataIC50: 157nMAssay Description:The assay buffer was formulated by removing 120 mL from a 1 L bottle of fresh, sterile dH2O (Mediatech, Herndon, Va.) and adding 100 mL of 10×HBSS th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2019
Entry Details
US Patent

TargetSodium channel protein type 9 subunit alpha(Human)
Purdue Pharma

US Patent
LigandPNGBDBM311147(US10155752, Compound 34 | (S)-2-(4-((7-chloro-1-me...)
Affinity DataIC50: 157nMAssay Description:In vitro assays were performed in a recombinant cell line expressing cDNA encoding the alpha subunit (Nav1.7, SCN9a, PN1, NE) of human Nav1.7 (Access...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2019
Entry Details
US Patent