BDBM311208 (S)-methyl (5-((2-amino-2,4-dimethylpentyl)oxy)-6-methyl-[2,4′-bipyridin]-2′-yl)carbamate::US10155760, Example 64::US10351563, Example 64::US10544120, Example 64::US10723734, Example 64::US10981910, Example 64::US9902722, Example 64

SMILES COC(=O)Nc1cc(ccn1)-c1ccc(OC[C@@](C)(N)CC(C)C)c(C)n1

InChI Key InChIKey=HINOQCZIDBNXEI-FQEVSTJZSA-N

Data  1 KI  23 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 24 hits for monomerid = 311208   

TargetAP2-associated protein kinase 1(Mouse)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311208((S)-methyl (5-((2-amino-2,4-dimethylpentyl)oxy)-6-...)
Affinity DataKi:  0.290nMAssay Description:Displacement of 3H-LP-927443 from AAK1 in C57BL6 mouse brain homogenate assessed as inhibition constant incubated for 1 hr by liquid scintillation co...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMyosin light chain kinase 2, skeletal/cardiac muscle(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311208((S)-methyl (5-((2-amino-2,4-dimethylpentyl)oxy)-6-...)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of MYLK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAP2-associated protein kinase 1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM311208((S)-methyl (5-((2-amino-2,4-dimethylpentyl)oxy)-6-...)
Affinity DataIC50:  1.10nMAssay Description:The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra...More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetAP2-associated protein kinase 1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM311208((S)-methyl (5-((2-amino-2,4-dimethylpentyl)oxy)-6-...)
Affinity DataIC50:  1.10nMAssay Description:The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra...More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetAP2-associated protein kinase 1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM311208((S)-methyl (5-((2-amino-2,4-dimethylpentyl)oxy)-6-...)
Affinity DataIC50:  1.10nMAssay Description:The assays were performed in U-bottom 384-well plates. The final assay volume was 30 Cl prepared from 15 μl additions of enzyme and substrates (...More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetAP2-associated protein kinase 1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM311208((S)-methyl (5-((2-amino-2,4-dimethylpentyl)oxy)-6-...)
Affinity DataIC50:  1.10nMAssay Description:The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra...More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetAP2-associated protein kinase 1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM311208((S)-methyl (5-((2-amino-2,4-dimethylpentyl)oxy)-6-...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of bacterially expressed GST-Xa-tagged human AAK1 using 5-FAM-labelled Aha-KEEQSQITSQVTGQIGWR-NH2 peptide as substrate incubated for 3 hrs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAP2-associated protein kinase 1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM311208((S)-methyl (5-((2-amino-2,4-dimethylpentyl)oxy)-6-...)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of full length human AAK1 expressed in HEK293F cells assessed as suppression of AP2 phosphorylation measured after 3 hrs by Western blot a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 3A4(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311208((S)-methyl (5-((2-amino-2,4-dimethylpentyl)oxy)-6-...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin) incubated for 10 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 1A2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311208((S)-methyl (5-((2-amino-2,4-dimethylpentyl)oxy)-6-...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP1A2 (unknown origin) incubated for 10 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 2C19(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311208((S)-methyl (5-((2-amino-2,4-dimethylpentyl)oxy)-6-...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin) incubated for 10 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 2C9(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311208((S)-methyl (5-((2-amino-2,4-dimethylpentyl)oxy)-6-...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin) incubated for 10 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 2D6(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311208((S)-methyl (5-((2-amino-2,4-dimethylpentyl)oxy)-6-...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin) incubated for 10 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 3A4(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311208((S)-methyl (5-((2-amino-2,4-dimethylpentyl)oxy)-6-...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP34A (unknown origin) using BFC as substrate incubated for 10 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 2B6(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311208((S)-methyl (5-((2-amino-2,4-dimethylpentyl)oxy)-6-...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP2B6 (unknown origin) incubated for 10 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311208((S)-methyl (5-((2-amino-2,4-dimethylpentyl)oxy)-6-...)
Affinity DataIC50:  5.90E+3nMAssay Description:Inhibition of human ERG by patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target5-hydroxytryptamine receptor 2B(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311208((S)-methyl (5-((2-amino-2,4-dimethylpentyl)oxy)-6-...)
Affinity DataIC50:  540nMAssay Description:Inhibition of 5HT2B receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetBMP-2-inducible protein kinase(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311208((S)-methyl (5-((2-amino-2,4-dimethylpentyl)oxy)-6-...)
Affinity DataIC50:  90nMAssay Description:Inhibition of BIKE (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDeath-associated protein kinase 1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311208((S)-methyl (5-((2-amino-2,4-dimethylpentyl)oxy)-6-...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of DAPK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCyclin-G-associated kinase(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311208((S)-methyl (5-((2-amino-2,4-dimethylpentyl)oxy)-6-...)
Affinity DataIC50:  210nMAssay Description:Inhibition of GAK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311208((S)-methyl (5-((2-amino-2,4-dimethylpentyl)oxy)-6-...)
Affinity DataIC50:  190nMAssay Description:Inhibition of MNK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311208((S)-methyl (5-((2-amino-2,4-dimethylpentyl)oxy)-6-...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of MNK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAP2-associated protein kinase 1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM311208((S)-methyl (5-((2-amino-2,4-dimethylpentyl)oxy)-6-...)
Affinity DataIC50:  1.10nMAssay Description:The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra...More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetAP2-associated protein kinase 1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM311208((S)-methyl (5-((2-amino-2,4-dimethylpentyl)oxy)-6-...)
Affinity DataIC50:  1.10nMAssay Description:The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra...More data for this Ligand-Target Pair
In DepthDetails US Patent