BDBM311268 (S)-1-((2′,4-bis(difluoromethyl)-[2,4′-bipyridin]-5-yl)oxy)-2,4-dimethylpentan-2-amine::US10155760, Example 124::US10351563, Example 124::US10544120, Example 124::US10723734, Example 124::US10981910, Example 124::US9902722, Example 124

SMILES CC(C)C[C@](C)(N)COc1cnc(cc1C(F)F)-c1ccnc(c1)C(F)F

InChI Key InChIKey=HVHRHDHQHUAOQI-IBGZPJMESA-N

Data  1 KI  36 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 37 hits for monomerid = 311268   

TargetAP2-associated protein kinase 1(Mouse)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311268((S)-1-((2′,4-bis(difluoromethyl)-[2,4′...)
Affinity DataKi:  0.0500nMAssay Description:Displacement of 3H-LP-927443 from AAK1 in C57BL6 mouse brain homogenate assessed as inhibition constant incubated for 1 hr by liquid scintillation co...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTRAF2 and NCK-interacting protein kinase(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311268((S)-1-((2′,4-bis(difluoromethyl)-[2,4′...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of TNIK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAP2-associated protein kinase 1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM311268((S)-1-((2′,4-bis(difluoromethyl)-[2,4′...)
Affinity DataIC50:  1.20nMAssay Description:The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra...More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetAP2-associated protein kinase 1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM311268((S)-1-((2′,4-bis(difluoromethyl)-[2,4′...)
Affinity DataIC50:  1.20nMAssay Description:The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra...More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetAP2-associated protein kinase 1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM311268((S)-1-((2′,4-bis(difluoromethyl)-[2,4′...)
Affinity DataIC50:  1.20nMAssay Description:The assays were performed in U-bottom 384-well plates. The final assay volume was 30 Cl prepared from 15 μl additions of enzyme and substrates (...More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetAP2-associated protein kinase 1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM311268((S)-1-((2′,4-bis(difluoromethyl)-[2,4′...)
Affinity DataIC50:  1.20nMAssay Description:The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra...More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetAP2-associated protein kinase 1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM311268((S)-1-((2′,4-bis(difluoromethyl)-[2,4′...)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of bacterially expressed GST-Xa-tagged human AAK1 using 5-FAM-labelled Aha-KEEQSQITSQVTGQIGWR-NH2 peptide as substrate incubated for 3 hrs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAP2-associated protein kinase 1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM311268((S)-1-((2′,4-bis(difluoromethyl)-[2,4′...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of full length human AAK1 expressed in HEK293F cells assessed as suppression of AP2 phosphorylation measured after 3 hrs by Western blot a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 3A4(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311268((S)-1-((2′,4-bis(difluoromethyl)-[2,4′...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin) incubated for 10 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 1A2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311268((S)-1-((2′,4-bis(difluoromethyl)-[2,4′...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP1A2 (unknown origin) incubated for 10 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 2C19(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311268((S)-1-((2′,4-bis(difluoromethyl)-[2,4′...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin) incubated for 10 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 2C9(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311268((S)-1-((2′,4-bis(difluoromethyl)-[2,4′...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin) incubated for 10 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 2D6(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311268((S)-1-((2′,4-bis(difluoromethyl)-[2,4′...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin) incubated for 10 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 3A4(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311268((S)-1-((2′,4-bis(difluoromethyl)-[2,4′...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP34A (unknown origin) using BFC as substrate incubated for 10 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 2B6(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311268((S)-1-((2′,4-bis(difluoromethyl)-[2,4′...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP2B6 (unknown origin) incubated for 10 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 3A4(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311268((S)-1-((2′,4-bis(difluoromethyl)-[2,4′...)
Affinity DataIC50: >2.00E+4nMAssay Description:Time dependent inhibition of CYP34A (unknown origin) using BFC as substrate incubated for 5 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 3A4(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311268((S)-1-((2′,4-bis(difluoromethyl)-[2,4′...)
Affinity DataIC50: >2.00E+4nMAssay Description:Time dependent inhibition of CYP34A (unknown origin) using BFC as substrate incubated for 30 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 3A4(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311268((S)-1-((2′,4-bis(difluoromethyl)-[2,4′...)
Affinity DataIC50: >4.00E+4nMAssay Description:Time dependent inhibition of CYP34A (unknown origin) using MDZ as substrate incubated for up to 30 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 3A4(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311268((S)-1-((2′,4-bis(difluoromethyl)-[2,4′...)
Affinity DataIC50: >4.00E+4nMAssay Description:Time dependent inhibition of CYP34A (unknown origin) using TST as substrate incubated for up to 30 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311268((S)-1-((2′,4-bis(difluoromethyl)-[2,4′...)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of human ERG by patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium-dependent noradrenaline transporter(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311268((S)-1-((2′,4-bis(difluoromethyl)-[2,4′...)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of NET (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311268((S)-1-((2′,4-bis(difluoromethyl)-[2,4′...)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of nicotinic acetylcholine receptor alpha 7 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSolute carrier organic anion transporter family member 1B1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311268((S)-1-((2′,4-bis(difluoromethyl)-[2,4′...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of OATP1B1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSolute carrier organic anion transporter family member 1B3(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311268((S)-1-((2′,4-bis(difluoromethyl)-[2,4′...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of OATP1B3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium/bile acid cotransporter(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311268((S)-1-((2′,4-bis(difluoromethyl)-[2,4′...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of NTCP (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetBile salt export pump(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311268((S)-1-((2′,4-bis(difluoromethyl)-[2,4′...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of BSEP (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetATP-binding cassette sub-family C member 2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311268((S)-1-((2′,4-bis(difluoromethyl)-[2,4′...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of MRP2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSolute carrier family 22 member 6(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311268((S)-1-((2′,4-bis(difluoromethyl)-[2,4′...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of OAT1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSolute carrier family 22 member 8(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311268((S)-1-((2′,4-bis(difluoromethyl)-[2,4′...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of OAT3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetBMP-2-inducible protein kinase(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311268((S)-1-((2′,4-bis(difluoromethyl)-[2,4′...)
Affinity DataIC50:  180nMAssay Description:Inhibition of BIKE (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCyclin-G-associated kinase(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311268((S)-1-((2′,4-bis(difluoromethyl)-[2,4′...)
Affinity DataIC50:  400nMAssay Description:Inhibition of GAK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311268((S)-1-((2′,4-bis(difluoromethyl)-[2,4′...)
Affinity DataIC50:  260nMAssay Description:Inhibition of MNK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311268((S)-1-((2′,4-bis(difluoromethyl)-[2,4′...)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of MNK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMyosin light chain kinase 2, skeletal/cardiac muscle(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311268((S)-1-((2′,4-bis(difluoromethyl)-[2,4′...)
Affinity DataIC50:  450nMAssay Description:Inhibition of MYLK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCitron Rho-interacting kinase(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311268((S)-1-((2′,4-bis(difluoromethyl)-[2,4′...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of CRIK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAP2-associated protein kinase 1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM311268((S)-1-((2′,4-bis(difluoromethyl)-[2,4′...)
Affinity DataIC50:  1.20nMAssay Description:The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra...More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetAP2-associated protein kinase 1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM311268((S)-1-((2′,4-bis(difluoromethyl)-[2,4′...)
Affinity DataIC50:  1.20nMAssay Description:The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra...More data for this Ligand-Target Pair
In DepthDetails US Patent