BDBM313806 US10167292, Example 50

SMILES Cc1nnn2CCN(c3ccc(Cl)cc3)c3cc(ccc3-c12)C(O)C(F)(F)F

InChI Key InChIKey=IENHPOBVKKOOQK-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 313806   

TargetBromodomain-containing protein 2 [91-163](Homo sapiens (Human))
Catalyst Therapeutics

US Patent
LigandPNGBDBM313806(US10167292, Example 50)
Affinity DataIC50:  550nMAssay Description:BRD binding and inhibition was assessed by measuring the interaction of biotinylated acetyl-histone H4 peptide (Anaspec #64989) with the BRD target p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 2 [364-436](Homo sapiens (Human))
Catalyst Therapeutics

US Patent
LigandPNGBDBM313806(US10167292, Example 50)
Affinity DataIC50:  550nMAssay Description:BRD binding and inhibition was assessed by measuring the interaction of biotinylated acetyl-histone H4 peptide (Anaspec #64989) with the BRD target p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [75-147](Homo sapiens (Human))
Catalyst Therapeutics

US Patent
LigandPNGBDBM313806(US10167292, Example 50)
Affinity DataIC50: <100nMAssay Description:BRD binding and inhibition was assessed by measuring the interaction of biotinylated acetyl-histone H4 peptide (Anaspec #64989) with the BRD target p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Walter and Eliza Hall Institute of Medical Research

Curated by ChEMBL
LigandPNGBDBM313806(US10167292, Example 50)
Affinity DataIC50:  23nMAssay Description:Inhibition of human His-tagged Brd4 bromodomain 2 expressed in Escherichia coli BL21 (DE3) preincubated for 30 mins followed by addition of biotinyla...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 2(Homo sapiens (Human))
Walter and Eliza Hall Institute of Medical Research

Curated by ChEMBL
LigandPNGBDBM313806(US10167292, Example 50)
Affinity DataIC50:  204nMAssay Description:Inhibition of human His-tagged Brd2 bromodomain 1 expressed in Escherichia coli BL21 (DE3) preincubated for 30 mins followed by addition of biotinyla...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 2(Homo sapiens (Human))
Walter and Eliza Hall Institute of Medical Research

Curated by ChEMBL
LigandPNGBDBM313806(US10167292, Example 50)
Affinity DataIC50:  370nMAssay Description:Inhibition of human His-tagged Brd2 bromodomain 2 expressed in Escherichia coli BL21 (DE3) preincubated for 30 mins followed by addition of biotinyla...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Walter and Eliza Hall Institute of Medical Research

Curated by ChEMBL
LigandPNGBDBM313806(US10167292, Example 50)
Affinity DataIC50:  43nMAssay Description:Inhibition of human His-tagged Brd4 bromodomain 1 expressed in Escherichia coli BL21 (DE3) preincubated for 30 mins followed by addition of biotinyla...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4 [368-440](Homo sapiens (Human))
Catalyst Therapeutics

US Patent
LigandPNGBDBM313806(US10167292, Example 50)
Affinity DataIC50: <100nMAssay Description:BRD binding and inhibition was assessed by measuring the interaction of biotinylated acetyl-histone H4 peptide (Anaspec #64989) with the BRD target p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent