BDBM315266 1-Methyl-3-{1-[5-methyl-2-(4-trifluoromethyl-phenyl)-1H-imidazol-4-ylmethyl]-piperidin-4-yl}-1,3-dihydro-benzoimidazol-2-one::US10172843, Example 1

SMILES Cc1[nH]c(-c2ccc(C(F)(F)F)cc2)nc1CN1CCC(n2c(=O)n(C)c3ccccc32)CC1

InChI Key InChIKey=GGYXPENBMYACGC-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 315266   

TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 315266BDBM315266(US10172843, Example 1 | 1-Methyl-3-{1-[5-methyl-2-...)
Affinity DataIC50: 280nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
US Patent