BDBM315297 2-(6-Chloro-3-{1-[5- methyl-2-(4- trifluoromethyl-phenyl)- 1H-imidazol-4- ylmethyl]-piperidin-4- yl}-2-oxo-2,3-dihydro- benzoimidazol-1-yl)- acetamide::US10172843, Example 31

SMILES Cc1[nH]c(-c2ccc(C(F)(F)F)cc2)nc1CN1CCC(n2c(=O)n(CC(N)=O)c3cc(Cl)ccc32)CC1

InChI Key InChIKey=JHWKFDWCARESTD-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 315297   

TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 315297BDBM315297(US10172843, Example 31 | 2-(6-Chloro-3-{1-[5- meth...)
Affinity DataIC50: 310nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
US Patent