BDBM315299 (6-Chloro-3-{1-[5- methyl-2-(4- trifluoromethyl-phenyl)- 1H-imidazol-4- ylmethyl]-piperidin-4- yl}-2-oxo-2,3-dihydro- benzoimidazol-1-yl)- acetic acid methyl ester::US10172843, Example 33

SMILES COC(=O)Cn1c(=O)n(C2CCN(Cc3nc(-c4ccc(C(F)(F)F)cc4)[nH]c3C)CC2)c2ccc(Cl)cc21

InChI Key InChIKey=RRYIQUKXKAODDS-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 315299   

TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 315299BDBM315299(US10172843, Example 33 | (6-Chloro-3-{1-[5- methyl...)
Affinity DataIC50: 130nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
US Patent