BDBM31530 2-methyl-5-[(methylamino)methyl]-N-[(1R)-1-(naphthalen-1-yl)ethyl]benzamide (I-2)::Substituted Benzamide Derivative, 49::med.21724, Compound 164

SMILES CNCc1ccc(C)c(c1)C(=O)N[C@H](C)c1cccc2ccccc12

InChI Key InChIKey=SIBDAZDNSVDATL-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 31530   

TargetReplicase polyprotein 1ab(SARS-CoV)
Purdue University

Curated by ChEMBL
LigandPNGBDBM31530(Substituted Benzamide Derivative, 49 | 2-methyl-5-...)
Affinity DataIC50: 360nMAssay Description:Inhibition of SARS-CoV-1 papain-like proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Purdue University

Curated by ChEMBL
LigandPNGBDBM31530(Substituted Benzamide Derivative, 49 | 2-methyl-5-...)
Affinity DataIC50: 480nMAssay Description:Inhibition of SARS-CoV-2 papain-like proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab [1541-1855](Human SARS coronavirus (SARS-CoV))
University of Illinois At Chicago

LigandPNGBDBM31530(Substituted Benzamide Derivative, 49 | 2-methyl-5-...)
Affinity DataIC50: 1.18E+3nMpH: 7.5Assay Description:done in a single pass in black 384-well plates (Matrix Technologies). The SARS-PLpro enzyme (20 nM final concentration) was prepared in an assay buff...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2015
Entry Details Article
PubMed
TargetReplicase polyprotein 1a(SARS-CoV)
University of Bonn

LigandPNGBDBM31530(Substituted Benzamide Derivative, 49 | 2-methyl-5-...)
Affinity DataIC50: 1.23E+3nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab [1541-1855](Human SARS coronavirus (SARS-CoV))
University of Illinois At Chicago

LigandPNGBDBM31530(Substituted Benzamide Derivative, 49 | 2-methyl-5-...)
Affinity DataIC50: 1.30E+3nMpH: 7.5 T: 2°CAssay Description:IC50 values for all inhibitors were determined using a 96-well plate based assay. Reactions were performed in buffer containing RLRGG-AMC, 2% DMSO, a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2009
Entry Details Article
PubMed