BDBM315311 3-{1-[2-(3-Chloro-4- trifluoromethyl-phenyl)- 5-methyl-1H-imidazol-4- ylmethyl]-piperidin-4- yl}-7-fluoro-3,4-dihydro- 1H-quinazolin-2-one::US10172843, Example 45::US10172843, Example 46

SMILES Cc1[nH]c(-c2ccc(C(F)(F)F)c(Cl)c2)nc1CN1CCC(c2c[nH]c3ncccc23)CC1

InChI Key InChIKey=VCGINKJSBHXSRP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 315311   

TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 315311BDBM315311(US10172843, Example 46 | 3-{1-[2-(3-Chloro-4- trif...)
Affinity DataIC50: 110nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
US Patent

TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 315311BDBM315311(US10172843, Example 46 | 3-{1-[2-(3-Chloro-4- trif...)
Affinity DataIC50: 305nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
US Patent