BDBM315314 3-{1-[2-(3,4-Dichloro- phenyl)-5-methyl-1H- imidazol-4-ylmethyl]- piperidin-4-yl}-7-fluoro- 3,4-dihydro-1H- quinazolin-2-one::US10172843, Example 48

SMILES Cc1[nH]c(-c2ccc(Cl)c(Cl)c2)nc1CN1CCC(N2Cc3ccc(F)cc3NC2=O)CC1

InChI Key InChIKey=NEBPVESQPAOAOY-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 315314   

TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 315314BDBM315314(US10172843, Example 48 | 3-{1-[2-(3,4-Dichloro- ph...)
Affinity DataIC50: 450nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
US Patent