BDBM315346 3-{1-[5-Methyl-2-(4- phenylmethanesulfonyl- phenyl)-1H-imidazol-4- ylmethyl]-piperidin-4- yl}-3,4-dihydro-1H- quinazolin-2-one::US10172843, Example 80

SMILES Cc1[nH]c(-c2ccc(S(=O)(=O)Cc3ccccc3)cc2)nc1CN1CCC(N2Cc3ccccc3NC2=O)CC1

InChI Key InChIKey=WVNBXTPLSSLAEJ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 315346   

TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 315346BDBM315346(US10172843, Example 80 | 3-{1-[5-Methyl-2-(4- phen...)
Affinity DataIC50: 99nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
US Patent