BDBM315723 US10172859, Example 144::US10172859, Example 145::US10172859, Example 146::US11065253, Example 146::US9732094, Example 146::[4-Fluoro-3-(6- morpholin-4-yl- thieno[3,2-d}- pyrimidin-4-yl)- phenyl]thiazol-2- yl-methanol1H NMR (500 MHz, DMSO-d6) ppm = 8.89 (s,1H), 7.76 (dd, J = 7.0, 2.3, 1H), 7.73 (d, J = 3.2,1H), 7.69-7.64 (m, 2H), 7.43-7.38 (m, 1H),6.96 (d, J = 4.6, 1H), 6.53 (s, 1H), 6.07 (d,J = 4.6, 1H), 3.77-3.71 (m, 4H), 3.44-3.38 (m,4H)

SMILES OC(c1nccs1)c1ccc(F)c(c1)-c1ncnc2cc(sc12)N1CCOCC1

InChI Key InChIKey=AIDFNPQAXSJWSH-UHFFFAOYSA-N

Data  6 KI  9 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 315723   

TargetDNA-dependent protein kinase catalytic subunit(Human)
Merck Patent

US Patent

LigandBDBM315723([4-Fluoro-3-(6- morpholin-4-yl- thieno[3,2-d}- pyr...)Copy SMILESCopy InChI

Affinity DataIC50: 3nMAssay Description:The kinase assay was carried out in streptavidin-coated 348-well microtitre flashplates. To this end, 1.5 μg of DNA-PK/protein complex and 100 n...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
4/30/2019
Entry Details
Copy BDB DOIUS Patent

Copy reaction URL

TargetDNA-dependent protein kinase catalytic subunit(Human)
Merck Patent

US Patent

LigandBDBM315723([4-Fluoro-3-(6- morpholin-4-yl- thieno[3,2-d}- pyr...)Copy SMILESCopy InChI

Affinity DataIC50: 3nMAssay Description:The kinase assay was carried out in streptavidin-coated 348-well microtitre flashplates. To this end, 1.5 μg of DNA-PK/protein complex and 100 n...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
4/30/2019
Entry Details
Copy BDB DOIUS Patent

Copy reaction URL

TargetDNA-dependent protein kinase catalytic subunit(Human)
Merck Patent

US Patent

LigandBDBM315723([4-Fluoro-3-(6- morpholin-4-yl- thieno[3,2-d}- pyr...)Copy SMILESCopy InChI

Affinity DataIC50: 3nMAssay Description:The kinase assay was carried out in streptavidin-coated 348-well microtitre flashplates. To this end, 1.5 μg of DNA-PK/protein complex and 100 n...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
4/30/2019
Entry Details
Copy BDB DOIUS Patent

Copy reaction URL

TargetDNA-dependent protein kinase catalytic subunit(Human)
Merck Patent

US Patent

LigandBDBM315723([4-Fluoro-3-(6- morpholin-4-yl- thieno[3,2-d}- pyr...)Copy SMILESCopy InChI

Affinity DataIC50: 3nMAssay Description:The kinase assay was carried out in streptavidin-coated 348-well microtitre flashplates. To this end, 1.5 ug of DNA-PK/protein complex and 100 ng of ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
6/23/2019
Entry Details
Copy BDB DOIUS Patent

Copy reaction URL

TargetDNA-dependent protein kinase catalytic subunit(Human)
Merck Patent

US Patent

LigandBDBM315723([4-Fluoro-3-(6- morpholin-4-yl- thieno[3,2-d}- pyr...)Copy SMILESCopy InChI

Affinity DataIC50: 3nMAssay Description:The kinase assay was carried out in streptavidin-coated 348-well microtitre flashplates. To this end, 1.5 ug of DNA-PK/protein complex and 100 ng of ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
6/23/2019
Entry Details
Copy BDB DOIUS Patent

Copy reaction URL

TargetDNA-dependent protein kinase catalytic subunit(Human)
Merck Patent

US Patent

LigandBDBM315723([4-Fluoro-3-(6- morpholin-4-yl- thieno[3,2-d}- pyr...)Copy SMILESCopy InChI

Affinity DataIC50: 3nMAssay Description:The kinase assay was carried out in streptavidin-coated 348-well microtitre flashplates. To this end, 1.5 μg of DNA-PK/protein complex and 100 n...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
12/19/2021
Entry Details
Copy BDB DOIUS Patent

Copy reaction URL

TargetDNA-dependent protein kinase catalytic subunit(Human)
Merck Patent

US Patent

LigandBDBM315723([4-Fluoro-3-(6- morpholin-4-yl- thieno[3,2-d}- pyr...)Copy SMILESCopy InChI

Affinity DataIC50: 3nMAssay Description:The kinase assay was carried out in streptavidin-coated 348-well microtitre flashplates. To this end, 1.5 μg of DNA-PK/protein complex and 100 n...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
12/19/2021
Entry Details
Copy BDB DOIUS Patent

Copy reaction URL

TargetDNA-dependent protein kinase catalytic subunit(Human)
Merck Patent

US Patent

LigandBDBM315723([4-Fluoro-3-(6- morpholin-4-yl- thieno[3,2-d}- pyr...)Copy SMILESCopy InChI

Affinity DataIC50: 3nMAssay Description:The kinase assay was carried out in streptavidin-coated 348-well microtitre flashplates. To this end, 1.5 ug of DNA-PK/protein complex and 100 ng of ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
6/23/2019
Entry Details
Copy BDB DOIUS Patent

Copy reaction URL

TargetDNA-dependent protein kinase catalytic subunit(Human)
Merck Patent

US Patent

LigandBDBM315723([4-Fluoro-3-(6- morpholin-4-yl- thieno[3,2-d}- pyr...)Copy SMILESCopy InChI

Affinity DataIC50: 3nMAssay Description:The kinase assay was carried out in streptavidin-coated 348-well microtitre flashplates. To this end, 1.5 μg of DNA-PK/protein complex and 100 n...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
12/19/2021
Entry Details
Copy BDB DOIUS Patent

Copy reaction URL

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Patent

US Patent

LigandBDBM315723([4-Fluoro-3-(6- morpholin-4-yl- thieno[3,2-d}- pyr...)Copy SMILESCopy InChI

Affinity DataKi:  2.00E+4nMAssay Description:Method for the detection and characterisation of test substances which interfere with the Kv11.1 (hERG) channel: Kv11.1 (hERG, human ether a-go-go re...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProtUniProtKB/TrEMBL
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
4/30/2019
Entry Details
Copy BDB DOIUS Patent

Copy reaction URL

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Patent

US Patent

LigandBDBM315723([4-Fluoro-3-(6- morpholin-4-yl- thieno[3,2-d}- pyr...)Copy SMILESCopy InChI

Affinity DataKi:  2.00E+4nMAssay Description:The patch-clamp measurement was carried out at room temperature in whole-cell configuration on human embryonic kidney cells (HEK293) which have been ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProtUniProtKB/TrEMBL
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
6/23/2019
Entry Details
Copy BDB DOIUS Patent

Copy reaction URL

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Patent

US Patent

LigandBDBM315723([4-Fluoro-3-(6- morpholin-4-yl- thieno[3,2-d}- pyr...)Copy SMILESCopy InChI

Affinity DataKi: >2.50E+4nMAssay Description:The patch-clamp measurement was carried out at room temperature in whole-cell configuration on human embryonic kidney cells (HEK293) which have been ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProtUniProtKB/TrEMBL
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
6/23/2019
Entry Details
Copy BDB DOIUS Patent

Copy reaction URL

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Patent

US Patent

LigandBDBM315723([4-Fluoro-3-(6- morpholin-4-yl- thieno[3,2-d}- pyr...)Copy SMILESCopy InChI

Affinity DataKi: >2.50E+4nMAssay Description:Method for the detection and characterisation of test substances which interfere with the Kv11.1 (hERG) channel: Kv11.1 (hERG, human ether a-go-go re...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProtUniProtKB/TrEMBL
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
4/30/2019
Entry Details
Copy BDB DOIUS Patent

Copy reaction URL

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Patent

US Patent

LigandBDBM315723([4-Fluoro-3-(6- morpholin-4-yl- thieno[3,2-d}- pyr...)Copy SMILESCopy InChI

Affinity DataKi: >2.50E+4nMAssay Description:Method for the detection and characterisation of test substances which interfere with the Kv11.1 (hERG) channel: Kv11.1 (hERG, human ether a-go-go re...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProtUniProtKB/TrEMBL
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
4/30/2019
Entry Details
Copy BDB DOIUS Patent

Copy reaction URL

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Patent

US Patent

LigandBDBM315723([4-Fluoro-3-(6- morpholin-4-yl- thieno[3,2-d}- pyr...)Copy SMILESCopy InChI

Affinity DataKi: >2.50E+4nMAssay Description:The patch-clamp measurement was carried out at room temperature in whole-cell configuration on human embryonic kidney cells (HEK293) which have been ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProtUniProtKB/TrEMBL
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
6/23/2019
Entry Details
Copy BDB DOIUS Patent

Copy reaction URL