BDBM315863 2-(4-Chlorothieno- [2,3-d}pyridazin-7-yl)- 2-[4-fluoro-3-(7- morpholin-4-yl- quinazolin-4-yl)- phenyl]acetamide1H NMR (500 MHz, DMSO-d6) ppm = 9.09 (s,1H), 8.41 (d, J = 5.4, 1H), 7.94 (s, 1H), 7.71-7.65(m, 3H), 7.56 (dd, J = 9.4, 3.1, 1H), 7.51 (dd,J = 9.4, 2.5, 1H), 7.48-7.40 (m, 2H), 7.20 (d,J = 2.4, 1H), 5.75 (s, 1H), 3.82-3.73 (m, 4H), 3.48-3.40 (m, 4H).::US10172859, Example 290::US11065253, Example 290::US9732094, Example 290

SMILES NC(=O)C(c1ccc(F)c(c1)-c1ncnc2cc(ccc12)N1CCOCC1)c1nnc(Cl)c2ccsc12

InChI Key InChIKey=YFPXALXVUKNUIN-UHFFFAOYSA-N

Data  2 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 315863   

TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM315863(2-(4-Chlorothieno- [2,3-d}pyridazin-7-yl)- 2-[4-fl...)
Affinity DataKi: <1.00E+4nMAssay Description:The patch-clamp measurement was carried out at room temperature in whole-cell configuration on human embryonic kidney cells (HEK293) which have been ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM315863(2-(4-Chlorothieno- [2,3-d}pyridazin-7-yl)- 2-[4-fl...)
Affinity DataKi: <1.00E+4nMAssay Description:Method for the detection and characterisation of test substances which interfere with the Kv11.1 (hERG) channel: Kv11.1 (hERG, human ether a-go-go re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM315863(2-(4-Chlorothieno- [2,3-d}pyridazin-7-yl)- 2-[4-fl...)
Affinity DataIC50:  5nMAssay Description:The kinase assay was carried out in streptavidin-coated 348-well microtitre flashplates. To this end, 1.5 μg of DNA-PK/protein complex and 100 n...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM315863(2-(4-Chlorothieno- [2,3-d}pyridazin-7-yl)- 2-[4-fl...)
Affinity DataIC50:  5nMAssay Description:The kinase assay was carried out in streptavidin-coated 348-well microtitre flashplates. To this end, 1.5 μg of DNA-PK/protein complex and 100 n...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM315863(2-(4-Chlorothieno- [2,3-d}pyridazin-7-yl)- 2-[4-fl...)
Affinity DataIC50:  5nMAssay Description:The kinase assay was carried out in streptavidin-coated 348-well microtitre flashplates. To this end, 1.5 ug of DNA-PK/protein complex and 100 ng of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent