BDBM316731 1-(4-{[7-(6-fluoropyridin-3-yl)-5H-pyrrolo[2,3-b]pyrazin-2-yl]oxy}piperidin-1-yl)prop-2-en-1-one::US20250134869, Example 226::US9617258, Example 226

SMILES Fc1ccc(cn1)-c1c[nH]c2ncc(OC3CCN(CC3)C(=O)C=C)nc12

InChI Key InChIKey=QMIKVVTUYYIJLW-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 316731   

TargetTyrosine-protein kinase JAK3(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 316731BDBM316731(1-(4-{[7-(6-fluoropyridin-3-yl)-5H-pyrrolo[2,3-b]p...)
Affinity DataIC50: 1nMAssay Description:Test article was solubilized in dimethyl sulfoxide (DMSO) to a stock concentration of 30 mM. An 11-point half log dilution series was created in DMSO...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2019
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 316731BDBM316731(1-(4-{[7-(6-fluoropyridin-3-yl)-5H-pyrrolo[2,3-b]p...)
Affinity DataIC50: 1nMAssay Description:Test article was solubilized in dimethyl sulfoxide (DMSO) to a stock concentration of 30 mM. An 11-point half log dilution series was created in DMSO...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2025
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 316731BDBM316731(1-(4-{[7-(6-fluoropyridin-3-yl)-5H-pyrrolo[2,3-b]p...)
Affinity DataIC50: 91nMAssay Description:Test article was solubilized in dimethyl sulfoxide (DMSO) to a stock concentration of 30 mM. An 11-point half log dilution series was created in DMSO...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2019
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 316731BDBM316731(1-(4-{[7-(6-fluoropyridin-3-yl)-5H-pyrrolo[2,3-b]p...)
Affinity DataIC50: 91nMAssay Description:Test article was solubilized in dimethyl sulfoxide (DMSO) to a stock concentration of 30 mM. An 11-point half log dilution series was created in DMSO...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2025
Entry Details
US Patent