BDBM317012 N-{3-[4-(1-Ethyl-1H-pyrazol- 4-ylamino)-7H-pyrrolo[2,3- d]pyrimidine-5-carbonyl]- 2,4-difluoro-phenyl}-4- trifluoromethyl- benzenesulfonamide::US9617267, Compound P-1063

SMILES CCn1cc(Nc2ncnc3[nH]cc(C(=O)c4c(F)ccc(NS(=O)(=O)c5ccc(cc5)C(F)(F)F)c4F)c23)cn1

InChI Key InChIKey=SDBDSUQMVGVRKH-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 317012   

TargetSerine/threonine-protein kinase B-raf(Human)
Plexxikon

US Patent
LigandChemical structure of BindingDB Monomer ID 317012BDBM317012(US9617267, Compound P-1063 | N-{3-[4-(1-Ethyl-1H-p...)
Affinity DataIC50: 100nMAssay Description:Assays for biochemical and cell based activity are known in the art, for example, as described in PCT publication WO 2007/002433, the disclosure of w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 317012BDBM317012(US9617267, Compound P-1063 | N-{3-[4-(1-Ethyl-1H-p...)
Affinity DataIC50: 100nMAssay Description:Assays for biochemical and cell based activity are known in the art, for example, as described in PCT publication WO 2007/002433, the disclosure of w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2019
Entry Details
US Patent

TargetEpidermal growth factor receptor [T790M,L858R](Human)
Plexxikon

US Patent
LigandChemical structure of BindingDB Monomer ID 317012BDBM317012(US9617267, Compound P-1063 | N-{3-[4-(1-Ethyl-1H-p...)
Affinity DataIC50: 100nMAssay Description:Assays for biochemical and cell based activity are known in the art, for example, as described in PCT publication WO 2007/002433, the disclosure of w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2019
Entry Details
US Patent

TargetCytochrome P450 3A4(Human)
Plexxikon

US Patent
LigandChemical structure of BindingDB Monomer ID 317012BDBM317012(US9617267, Compound P-1063 | N-{3-[4-(1-Ethyl-1H-p...)
Affinity DataIC50: 5.00E+3nMAssay Description:The inhibition of CYP enzyme activity (IC50) for each of CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4(BFC) and CYP3A4(BQ) is determined for compounds, whe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2019
Entry Details
US Patent

TargetCytochrome P450 2C19(Human)
Plexxikon

US Patent
LigandChemical structure of BindingDB Monomer ID 317012BDBM317012(US9617267, Compound P-1063 | N-{3-[4-(1-Ethyl-1H-p...)
Affinity DataIC50: 7.50E+3nMAssay Description:The inhibition of CYP enzyme activity (IC50) for each of CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4(BFC) and CYP3A4(BQ) is determined for compounds, whe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2019
Entry Details
US Patent

TargetCytochrome P450 2C9(Human)
Plexxikon

US Patent
LigandChemical structure of BindingDB Monomer ID 317012BDBM317012(US9617267, Compound P-1063 | N-{3-[4-(1-Ethyl-1H-p...)
Affinity DataIC50: 7.50E+3nMAssay Description:The inhibition of CYP enzyme activity (IC50) for each of CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4(BFC) and CYP3A4(BQ) is determined for compounds, whe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2019
Entry Details
US Patent

TargetCytochrome P450 3A4(Human)
Plexxikon

US Patent
LigandChemical structure of BindingDB Monomer ID 317012BDBM317012(US9617267, Compound P-1063 | N-{3-[4-(1-Ethyl-1H-p...)
Affinity DataIC50: 7.50E+3nMAssay Description:The inhibition of CYP enzyme activity (IC50) for each of CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4(BFC) and CYP3A4(BQ) is determined for compounds, whe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2019
Entry Details
US Patent

TargetCytochrome P450 1A2(Human)
Plexxikon

US Patent
LigandChemical structure of BindingDB Monomer ID 317012BDBM317012(US9617267, Compound P-1063 | N-{3-[4-(1-Ethyl-1H-p...)
Affinity DataIC50: 1.00E+4nMAssay Description:The inhibition of CYP enzyme activity (IC50) for each of CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4(BFC) and CYP3A4(BQ) is determined for compounds, whe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2019
Entry Details
US Patent

TargetCytochrome P450 2D6(Human)
Plexxikon

US Patent
LigandChemical structure of BindingDB Monomer ID 317012BDBM317012(US9617267, Compound P-1063 | N-{3-[4-(1-Ethyl-1H-p...)
Affinity DataIC50: 1.00E+4nMAssay Description:The inhibition of CYP enzyme activity (IC50) for each of CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4(BFC) and CYP3A4(BQ) is determined for compounds, whe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2019
Entry Details
US Patent