BDBM317146 3-Methyl-6-((1-methyl-5-(pyrrolidin-1-yl)-1H-1,2,4-triazol-3-yl)ethynyl)-2-(trifluoromethyl)imidazo[1,2-b]pyridazine::Roche-Dataset for PDE10A, Compound 389::US9617271, 4

SMILES Cc1c(nc2ccc(nn12)C#Cc1nc(N2CCCC2)n(C)n1)C(F)(F)F

InChI Key InChIKey=XVPXLEGBDKQZTL-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 317146   

LigandPNGBDBM317146(3-Methyl-6-((1-methyl-5-(pyrrolidin-1-yl)-1H-1,2,4...)
Affinity DataIC50: 3.92nMAssay Description:Human PDE10A IC50 values were determined by using purified enzyme (Biomol cat. # SE-534) in a scintillation proximity assay (SPA) in 96 well plates (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2022
Entry Details Article
PubMed
LigandPNGBDBM317146(3-Methyl-6-((1-methyl-5-(pyrrolidin-1-yl)-1H-1,2,4...)
Affinity DataIC50: 4nMAssay Description:The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 μl contained 20 mM HEPES pH=7.5/10 mM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2019
Entry Details
US Patent