BDBM317627 3-(4-{5- Amino-4-[4- (4-methyl- piperazine-1- carbonyl)-1H- indole-2- carbonyl]- pyrazol-1-yl}- 3-methyl- phenoxy)- benzonitrile::US10640491, Compound 16::US11104668, Compound 16::US9624201, Compound 16

SMILES Cc1cc(Oc2cccc(C#N)c2)ccc1-n1ncc(C(=O)c2cc3c(C(=O)N4CCN(C)CC4)cccc3[nH]2)c1N

InChI Key InChIKey=CUVYYWGTVSAMJR-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 317627   

TargetTyrosine-protein kinase BTK(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 317627BDBM317627(US9624201, Compound 16 | 3-(4-{5- Amino-4-[4- (4-m...)
Affinity DataIC50: 39.1nMAssay Description:This BTK competition assay measures compound potency (IC50) for the inactivated state of Bruton's Tyrosine Kinase using FRET (F rster/Fluorescenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 317627BDBM317627(US9624201, Compound 16 | 3-(4-{5- Amino-4-[4- (4-m...)
Affinity DataIC50: 39.1nMAssay Description:The assay is a capture of radioactive 33P phosphorylated product through filtration. The interactions of Btk, biotinylated SH2 peptide substrate (Src...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 317627BDBM317627(US9624201, Compound 16 | 3-(4-{5- Amino-4-[4- (4-m...)
Affinity DataIC50: 39.1nMAssay Description:This BTK competition assay measures compound potency (IC50) for the inactivated state of Bruton's Tyrosine Kinase using FRET (F rster/Flouresence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2021
Entry Details
US Patent