BDBM3177 Bisindolylmaleimide 11d::ROCHE screening, 58::[(5-{3-[4-(1-methyl-1H-indol-3-yl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]-1H-indol-1-yl}pentyl)sulfanyl]methanimidamide

SMILES Cn1cc(C2=C(C(=O)NC2=O)c2cn(CCCCCSC(N)=N)c3ccccc23)c2ccccc12

InChI Key InChIKey=HPYZDMGHSZUKPM-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 3177   Sort by

TargetProtein kinase C beta type(Rat)
Roche Products

LigandPNGBDBM3177([(5-{3-[4-(1-methyl-1H-indol-3-yl)-2,5-dioxo-2,5-d...)
Affinity DataIC50: 47nMAssay Description:The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM3177([(5-{3-[4-(1-methyl-1H-indol-3-yl)-2,5-dioxo-2,5-d...)
Affinity DataIC50: 4.60E+3nMAssay Description:The activity of PKA, activated by cAMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase TBK1(Human)
Technical University of Dortmund

LigandPNGBDBM3177([(5-{3-[4-(1-methyl-1H-indol-3-yl)-2,5-dioxo-2,5-d...)
Affinity DataIC50: 376nMAssay Description:IC50 determinations for TBK1 were performed with the KinEASE-STK assay from Cisbio according to the manufacturer's instructions. A biotinylated s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed