BDBM318163 US10301317, Example 119::US9624228, Example 119

SMILES COc1ncc(-c2n[nH]c3cc4c(cc23)CN(Cc2cccc(C(F)(F)F)c2)C(=O)N4)cn1

InChI Key InChIKey=MCHSHGYKWRSKQV-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 318163   

TargetMitogen-activated protein kinase 1(Human)
Kura Oncology

US Patent
LigandChemical structure of BindingDB Monomer ID 318163BDBM318163(US9624228, Example 119 | US10301317, Example 119)
Affinity DataIC50: 50nMAssay Description:The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2020
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Kura Oncology

US Patent
LigandChemical structure of BindingDB Monomer ID 318163BDBM318163(US9624228, Example 119 | US10301317, Example 119)
Affinity DataIC50: 50nMAssay Description:The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
US Patent