BDBM318200 US10301317, Example 156::US9624228, Example 156

SMILES Cc1cc(-c2n[nH]c3cc4c(cc23)CN([C@@H]2CCCN(Cc3cccc(Cl)c3)C2)C(=O)N4)ccn1

InChI Key InChIKey=FEAQCACBMPYEFJ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 318200   

TargetMitogen-activated protein kinase 1(Human)
Kura Oncology

US Patent
LigandChemical structure of BindingDB Monomer ID 318200BDBM318200(US9624228, Example 156 | US10301317, Example 156)
Affinity DataIC50: 50nMAssay Description:The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2020
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Kura Oncology

US Patent
LigandChemical structure of BindingDB Monomer ID 318200BDBM318200(US9624228, Example 156 | US10301317, Example 156)
Affinity DataIC50: 50nMAssay Description:The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Kura Oncology

US Patent
LigandChemical structure of BindingDB Monomer ID 318200BDBM318200(US9624228, Example 156 | US10301317, Example 156)
Affinity DataIC50: 50nMAssay Description:The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2020
Entry Details
US Patent