BDBM318477 7-(3,5-Dimethylisoxazol-4-yl)-N-ethyl-2-oxo-4-phenyl-1,2,4,5-tetrahydroimidazo[1,5,4-de][1,4]benzoxazine-5-carboxamide::US10464947, Example 24A::US9624241, Example 24A

SMILES CCNC(=O)C1Oc2c(ccc3[nH]c(=O)n([C@H]1c1ccccc1)c23)-c1c(C)noc1C

InChI Key InChIKey=PSRMPHQLYKFBNC-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 318477   

TargetBromodomain-containing protein 4 [342-460](Human)
Incyte

US Patent
LigandPNGBDBM318477(7-(3,5-Dimethylisoxazol-4-yl)-N-ethyl-2-oxo-4-phen...)
Affinity DataIC50: 100nMAssay Description:BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
US Patent

TargetBromodomain-containing protein 4 [342-460](Human)
Incyte

US Patent
LigandPNGBDBM318477(7-(3,5-Dimethylisoxazol-4-yl)-N-ethyl-2-oxo-4-phen...)
Affinity DataIC50: 100nMAssay Description:BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/9/2020
Entry Details
US Patent

TargetBromodomain-containing protein 4 [49-170](Human)
Incyte

US Patent
LigandPNGBDBM318477(7-(3,5-Dimethylisoxazol-4-yl)-N-ethyl-2-oxo-4-phen...)
Affinity DataIC50: 550nMAssay Description:BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
US Patent

TargetBromodomain-containing protein 4 [42-168](Human)
Incyte Holdings

US Patent
LigandPNGBDBM318477(7-(3,5-Dimethylisoxazol-4-yl)-N-ethyl-2-oxo-4-phen...)
Affinity DataIC50: 550nMAssay Description:BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/9/2020
Entry Details
US Patent