BDBM318718 (3R)-1-[(4S)-7-(3,5-dimethylisoxazol-4- yl)-4-pyridin-2-yl-4,5- dihydroimidazo[1,5,4- de][1,4]benzoxazin-2-yl]-N- ethylpyrrolidine-3-carboxamide::US10464947, Example 250::US11498926, Example 250::US9624241, Example 250

SMILES CCNC(=O)[C@@H]1CCN(C1)c1nc2ccc(-c3c(C)noc3C)c3OC[C@H](c4ccccn4)n1c23

InChI Key InChIKey=HKJPLBOSNZJHQV-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 318718   

TargetBromodomain-containing protein 4 [58-164](Human)
Incyte

US Patent
LigandPNGBDBM318718(US9624241, Example 250 | (3R)-1-[(4S)-7-(3,5-dimet...)
Affinity DataIC50: 100nMAssay Description:Table 11: BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2023
Entry Details
US Patent

TargetBromodomain-containing protein 4 [353-454](Human)
Incyte

US Patent
LigandPNGBDBM318718(US9624241, Example 250 | (3R)-1-[(4S)-7-(3,5-dimet...)
Affinity DataIC50: 100nMAssay Description:Table 12: BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2023
Entry Details
US Patent

TargetBromodomain-containing protein 4 [342-460](Human)
Incyte Holdings

US Patent
LigandPNGBDBM318718(US9624241, Example 250 | (3R)-1-[(4S)-7-(3,5-dimet...)
Affinity DataIC50: 100nMAssay Description:BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/9/2020
Entry Details
US Patent

TargetBromodomain-containing protein 4 [49-170](Human)
Incyte

US Patent
LigandPNGBDBM318718(US9624241, Example 250 | (3R)-1-[(4S)-7-(3,5-dimet...)
Affinity DataIC50: 100nMAssay Description:BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
US Patent

TargetBromodomain-containing protein 4 [342-460](Human)
Incyte Holdings

US Patent
LigandPNGBDBM318718(US9624241, Example 250 | (3R)-1-[(4S)-7-(3,5-dimet...)
Affinity DataIC50: 100nMAssay Description:BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
US Patent

TargetBromodomain-containing protein 4 [42-168](Human)
Incyte Holdings

US Patent
LigandPNGBDBM318718(US9624241, Example 250 | (3R)-1-[(4S)-7-(3,5-dimet...)
Affinity DataIC50: 100nMAssay Description:BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 40 μL for BD1 and 60 μL for BD2. Inhib...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/9/2020
Entry Details
US Patent