BDBM319469 (3-cyanophenyl) methyl N-{4-[2- ({[(cyclopropyl- carbamoyl) methyl] carbamoyl}(3,3,3- trifluoropropane- sulfonyl)methyl)- 5-fluoro-1,3- benzothiazol- 6-yl]phenyl} carbamate::US10173991, Example 522

SMILES Fc1cc2nc(sc2cc1-c1ccc(NC(=O)OCc2cccc(c2)[N+]#[C-])cc1)C(C(=O)NCC(=O)NC1CC1)S(=O)(=O)CCC(F)(F)F

InChI Key InChIKey=BKKRNBBVLVPNFE-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 319469   

TargetEndothelial lipase(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM319469((3-cyanophenyl) methyl N-{4-[2- ({[(cyclopropyl- c...)
Affinity DataIC50: 1nMAssay Description:Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
US Patent