BDBM31974 Dipeptidyl nitrile inhibitor, 7

SMILES Cc1ccc(cc1)C(=O)N[C@@H](Cc1cccc(Cl)c1)C(=O)NCC#N

InChI Key InChIKey=BKCDUCVFMKULOP-KRWDZBQOSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 31974   

TargetProcathepsin L [114-333,T223A](Human)
Astrazeneca

LigandPNGBDBM31974(Dipeptidyl nitrile inhibitor, 7)
Affinity DataIC50:  251nMpH: 7.0 T: 37°CAssay Description:IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCathepsin L2(Human)
Astrazeneca

LigandPNGBDBM31974(Dipeptidyl nitrile inhibitor, 7)
Affinity DataIC50:  1.00E+3nMpH: 7.0 T: 37°CAssay Description:IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCathepsin B(Human)
Astrazeneca

LigandPNGBDBM31974(Dipeptidyl nitrile inhibitor, 7)
Affinity DataIC50:  2.51E+3nMAssay Description:IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCathepsin K(Human)
Astrazeneca

LigandPNGBDBM31974(Dipeptidyl nitrile inhibitor, 7)
Affinity DataIC50:  1.26E+3nMAssay Description:IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCathepsin S(Human)
Astrazeneca

LigandPNGBDBM31974(Dipeptidyl nitrile inhibitor, 7)
Affinity DataIC50:  631nMAssay Description:IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed