BDBM31986 Dipeptidyl nitrile inhibitor, 19

SMILES Cc1cc(C(=O)N[C@@H](Cc2cccc(Cl)c2)C(=O)NCC#N)n(C)n1

InChI Key InChIKey=MNOJZNBDQCIJLT-AWEZNQCLSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 31986   

TargetProcathepsin L [114-333,T223A](Human)
Astrazeneca

LigandPNGBDBM31986(Dipeptidyl nitrile inhibitor, 19)
Affinity DataIC50:  501nMpH: 7.0 T: 37°CAssay Description:IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCathepsin L2(Human)
Astrazeneca

LigandPNGBDBM31986(Dipeptidyl nitrile inhibitor, 19)
Affinity DataIC50:  1.26E+3nMAssay Description:IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCathepsin B(Human)
Astrazeneca

LigandPNGBDBM31986(Dipeptidyl nitrile inhibitor, 19)
Affinity DataIC50: >1.00E+4nMAssay Description:IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCathepsin K(Human)
Astrazeneca

LigandPNGBDBM31986(Dipeptidyl nitrile inhibitor, 19)
Affinity DataIC50:  6.31E+3nMAssay Description:IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCathepsin S(Human)
Astrazeneca

LigandPNGBDBM31986(Dipeptidyl nitrile inhibitor, 19)
Affinity DataIC50:  794nMAssay Description:IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed