BDBM321292 5-cyclopropyl-N-((2S)-2-methyl-1- (vinylsulfonyl)piperidin-4-yl) isoxazole-3-carboxamide::US10179773, Compound 6::US10669243, Compound 6

SMILES C[C@H]1CC(CCN1S(=O)(=O)C=C)NC(=O)c1cc(on1)C1CC1

InChI Key InChIKey=WCXOHKPYBYVLEG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 321292   

TargetHistone-lysine N-methyltransferase SMYD3(Human)
Epizyme

US Patent
LigandPNGBDBM321292(5-cyclopropyl-N-((2S)-2-methyl-1- (vinylsulfonyl)p...)
Affinity DataIC50: 5.28E+3nMAssay Description:The assays were an performed in a buffer consisting of 25 mM Tris-Cl pH 8.0, 1 mM TCEP, 0.005% BSG, and 0.005% Tween 20, prepared on the day of use. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase SMYD3(Human)
Epizyme

US Patent
LigandPNGBDBM321292(5-cyclopropyl-N-((2S)-2-methyl-1- (vinylsulfonyl)p...)
Affinity DataIC50: 5.28E+3nMAssay Description:The assays were all performed in a buffer consisting of 25 mM Tris-Cl pH 8.0, 1 mM TCEP, 0.005% BSG, and 0.005% Tween 20, prepared on the day of use....More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent