BDBM32377 adenosine-derived inhibitor (Grp78), 12::adenosine-derived inhibitor, 11
SMILES Nc1ncnc2n([C@@H]3O[C@H](COCc4ccccc4)[C@@H](O)[C@H]3O)c(NCc3ccc(Cl)c(Cl)c3)nc12
InChI Key InChIKey=PTHFXORLUDDFQZ-ZDXOVATRSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 32377
Affinity DataKi: 1.05E+3nM ΔG°: -8.15kcal/molepH: 7.4 T: 25°CAssay Description:The assay was based on the fluorescence polarization of the unbound small binding partner will be low, and its binding to a larger binding partner wi...More data for this Ligand-Target Pair
Affinity DataIC50: 2.40E+3nMpH: 7.4 T: 23°CAssay Description:A fluorescein-labeled ATP-based probe was utilized, which binds to the GST fused ATPase domain (amino acids 3-383) of HSP70, producing an increase in...More data for this Ligand-Target Pair
Affinity DataKd: 770nM Kon: 0.300M-1s-1pH: 7.4 T: 25°CAssay Description:SPR measurements wereperformed on BIAcore T100 instrument (BIAcore GE Healthcare), at25 C on series S NTA chips (certified) according to provider'...More data for this Ligand-Target Pair