BDBM323978 US10189794, Compound I-232::US10618902, Compound I-232::US10774052, Compound I-232

SMILES CCC(=O)Nc1cccc(CN2C(=O)N(Cc3cnc(Nc4cccc(NC(=O)C=C)c4)nc23)c2c(Cl)c(OC)cc(OC)c2Cl)c1

InChI Key InChIKey=BSIYVTXTINKFOA-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 323978   

TargetFibroblast growth factor receptor 4(Human)
Celgene Car

US Patent
LigandPNGBDBM323978(US10189794, Compound I-232 | US10618902, Compound ...)
Affinity DataIC50: 100nMAssay Description:MDA-MB-453 and Huh7 cells were grown in 96-well poly-D-lysine plates (BD Bioscience, San Jose, Calif.) to 90% confluence. The cells were then incubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2021
Entry Details
US Patent

TargetFibroblast growth factor receptor 4(Human)
Celgene Car

US Patent
LigandPNGBDBM323978(US10189794, Compound I-232 | US10618902, Compound ...)
Affinity DataIC50: 100nMAssay Description:A 10× stock solution of FGFR4-WT (PR4380C), (from Invitrogen, Carlsbad, Calif.) corresponding to method a in Table 7, was prepared as described below...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2019
Entry Details
US Patent

TargetFibroblast growth factor receptor 4(Human)
Celgene Car

US Patent
LigandPNGBDBM323978(US10189794, Compound I-232 | US10618902, Compound ...)
Affinity DataIC50: 500nMAssay Description:A 10× stock solution of FGFR4-WT (PR4380C or P3054), (from Invitrogen, Carlsbad, Calif.) corresponding to method a in Table 10, was prepared as descr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
US Patent