BDBM324342 5-(tert-butyl)-4-methyl- N-(2-(2-((1-methyl-1H- pyrazol-4- yl)amino)pyrimidin-4- yl)-6,7,8,9-tetrahydro- 5H-benzo[7]annulen-5- yl)-4H-1,2,4-triazole-3- carboxamide::US10189829, Compound 116::US10227341, Compound 116::US10961237, Compound 116::US11858926, Compound 116

SMILES Cn1cc(Nc2nccc(n2)-c2ccc3C(CCCCc3c2)NC(=O)c2nnc(n2C)C(C)(C)C)cn1

InChI Key InChIKey=DQLBEZLARAKITM-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 324342   

TargetTyrosine-protein kinase BTK [14-552](Human)
Biogen Ma

US Patent
LigandPNGBDBM324342(5-(tert-butyl)-4-methyl- N-(2-(2-((1-methyl-1H- py...)
Affinity DataIC50: 1nMAssay Description:The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2024
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Biogen Ma

US Patent
LigandPNGBDBM324342(5-(tert-butyl)-4-methyl- N-(2-(2-((1-methyl-1H- py...)
Affinity DataIC50: 1nMAssay Description:The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Biogen Ma

US Patent
LigandPNGBDBM324342(5-(tert-butyl)-4-methyl- N-(2-(2-((1-methyl-1H- py...)
Affinity DataIC50: 1nMAssay Description:The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2019
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Biogen Ma

US Patent
LigandPNGBDBM324342(5-(tert-butyl)-4-methyl- N-(2-(2-((1-methyl-1H- py...)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of human BTK using fluorescein-labeled polyGAT peptide as substrate incubated for 30 mins by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Biogen Ma

US Patent
LigandPNGBDBM324342(5-(tert-butyl)-4-methyl- N-(2-(2-((1-methyl-1H- py...)
Affinity DataIC50: 505nMAssay Description:The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent