BDBM324349 (R)-5-(tert-butyl)-N-(8- (2-((5,6-dihydro-4H- pyrrolo[1,2-b]pyrazol-3- yl)amino)pyrimidin-4- yl)-2-(2-hydroxyethyl)- 2,3,4,5-tetrahydro-1H- benzo[c]azepin-5-yl)- 1,2,4-oxadiazole-3- carboxamide::US10189829, Compound 149::US10227341, Compound 149::US10961237, Compound 149::US11858926, Compound 149

SMILES CC(C)(C)c1nc(no1)C(=O)N[C@@H]1CCN(CCO)Cc2cc(ccc12)-c1ccnc(Nc2cnn3CCCc23)n1

InChI Key InChIKey=FIPOBCPMTJZNKK-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 324349   

TargetTyrosine-protein kinase BTK(Human)
Biogen Ma

US Patent
LigandPNGBDBM324349((R)-5-(tert-butyl)-N-(8- (2-((5,6-dihydro-4H- pyrr...)
Affinity DataIC50: 1nMAssay Description:The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2019
Entry Details
US Patent

TargetTyrosine-protein kinase BTK [14-552](Human)
Biogen Ma

US Patent
LigandPNGBDBM324349((R)-5-(tert-butyl)-N-(8- (2-((5,6-dihydro-4H- pyrr...)
Affinity DataIC50: 1nMAssay Description:The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2024
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Biogen Ma

US Patent
LigandPNGBDBM324349((R)-5-(tert-butyl)-N-(8- (2-((5,6-dihydro-4H- pyrr...)
Affinity DataIC50: 1nMAssay Description:The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Biogen Ma

US Patent
LigandPNGBDBM324349((R)-5-(tert-butyl)-N-(8- (2-((5,6-dihydro-4H- pyrr...)
Affinity DataIC50: 505nMAssay Description:The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent